Selective permeability of gap junction channels
نویسندگان
چکیده
منابع مشابه
Selective permeability of gap junction channels.
Gap junctions mediate the transfer of small cytoplasmic molecules between adjacent cells. A family of gap junction proteins exist that form channels with unique properties, and differ in their ability to mediate the transfer of specific molecules. Mutations in a number of individual gap junction proteins, called connexins, cause specific human diseases. Therefore, it is important to understand ...
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Gap junctions are thought to mediate the direct intercellular coupling of adjacent cells by the gating of an aqueous pore permeable to ions and molecules of up to 1 kD or 8 to 14 A in diameter. We performed ion-substitution and dye-transfer experiments to determine the relative Cl-/K conductance and dye permeability of anionic fluorescein derivatives in chick connexin45 (Cx45) channels. We demo...
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DNAs coding for seven murine connexins (Cx) (Cx26, Cx31, Cx32, Cx37, Cx40, Cx43, and Cx45) are functionally expressed in human HeLa cells that were deficient in gap junctional communication. We compare the permeabilities of gap junctions comprised of different connexins to iontophoretically injected tracer molecules. Our results show that Lucifer yellow can pass through all connexin channels an...
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Gap junction channels exhibit connexin dependent biophysical properties, including selective intercellular passage of larger solutes, such as second messengers and siRNA. Here, we report the determination of cyclic nucleotide (cAMP) permeability through gap junction channels composed of Cx43, Cx40, or Cx26 using simultaneous measurements of junctional conductance and intercellular transfer of c...
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In many tissues cells communicate directly through arrays of intercellular channels which are organized to form gap junctions. These channels are permeant to inorganic ions as well as to small hydrophilic molecules up to Mr 2000. The electrical and chemical coupling provided by such junctions is under the control of intracellular and, in many cases, extracellular substances. The latter (hormone...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2004
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2003.11.022